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apalutamide will lower the extent or impact of modafinil by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Keep away from or Use Alternate Drug. Coadministration of apalutamide, a strong CYP3A4 inducer, with drugs which can be CYP3A4 substrates can result in decrease publicity to these prescription drugs.It isn't acknowledged no matter whet